Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for a highly motivated and driven biochemist/enzymologist to join the Discovery Biology team at Revolution Medicines. The ideal candidate will have a deep knowledge of enzyme kinetics, excitement about investigating detailed biochemical mechanisms, and the ability to apply this knowledge to practical, data-driven decisions. The scientist in this position will:

• Design, develop, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and enable hit finding and validation efforts.
• Perform kinetic studies to support a deep understanding of small molecules with complex mechanisms of action, including covalent and non-covalent molecular glue inhibitors and activators.
• Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities.
• Support cross-functional teams to generate novel insights and drive drug discovery and development.
• Effectively communicate findings to diverse audiences through presentations, reports, and publications.

Required Skills, Experience and Education:

• Ph.D. in Biochemistry, Enzymology, Chemical Biology, or a related field with 5-8 years of experience, preferably in an industrial setting.
• Thorough understanding of enzyme kinetics and the ability to design, analyze, and interpret experimental results.
• Hands-on experience handling recombinant proteins and analyzing activity through experimental assays (fluorescence, absorbance, luminescence, FRET, mass spectrometry, etc.).
• Rigorous and detail-oriented approach to data analysis and interpretation.
• Knowledge of protein structure-function interpretation and proficiency with software to visualize protein structures.
• Strong analytical and problem-solving skills with the ability to work independently.
• Excellent written and verbal communication skills, including the ability to communicate complex concepts to a variety of audiences.

Preferred Skills:

• Experience in target ID and hit ID stage programs in biotech.
• Proficient with software to model multi-step enzyme reactions (DynaFit, SimBiology, PySB, etc.).
• Familiarity with modern laboratory automation, data systems, and analytics and ability to design experiments to take advantage of these systems. #LI-Hybrid #LI-LN1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [click to reveal email address] privacy@revmed.com .

Base Pay Salary Range

$144,000-$180,000 USD

Job Tags

Full time, Local area,

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